By examining splicing changes in neuronal nuclei depleted of TDP-4340, we found 12 overlapping differentially spliced genes (encompassing 17 splicing events) with ALS iPSMNs (including POLDIP3, PPP6R3, CAMK2B, CEP290; Supplementary Data 9)40. The gene discussed is POLDIP3; the disease is amyotrophic lateral sclerosis.