Interrogating individual genes constituting the TP53 TF regulon revealed the greatest increases in ALS iPSMNs in TNFRSF10B, SESN1, RRM2B, CDKN1A, ZMAT3 and MDM2. These integrated analysis results can be easily explored in the interactive web application at https://oliverziff.shinyapps.io/als_genome_instability/. This evidence concerns the gene CDKN1A and amyotrophic lateral sclerosis.