Correlating transcriptome-wide gene expression changes between ALS genetic backgrounds revealed weak associations, with the strongest correlation between SOD1 and sporadic lines (Pearson R = + 0.38, p < 2.2 × 10−16) and the weakest between SOD1 and TARDBP (R = −0.14, p < 2.2 × 10−16; Fig. 3f, Supplementary Fig. 12a). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.