Amongst the genes exhibiting differential splicing in ALS were a significant number of genes involved with p53 and DNA repair (including POLM, METTL22, HUWE1, HDAC1, MTA1, PMS1, ZSWIM7; Fisher exact test p = 2.3 × 10−8). The gene discussed is PMS1; the disease is amyotrophic lateral sclerosis.