TP53 and amyotrophic lateral sclerosis: Likewise, in non-TDP-43 ALS iPSMNs, the TP53 TF was mildly decreased in activity (NES = −1.6, p = 0.12), whereas in TDP-43 ALS iPSMNs TP53 was the most strongly upregulated TF (NES + 7.4, p < 0.001; Supplementary Fig. 15a, b).