Amongst the differential splicing events in ALS post-mortem were 4 established ALS genes (CAMTA1, NEK1, ATXN1, and GRIN1), 19 genes with altered splicing in neuronal nuclei depleted of TDP-43 (including KALRN, PRUNE2, DNM1) and 11 genes with altered splicing in TDP-43 knockdown (e.g. KALRN, DNM1, NEK1; Fig. 5i, Supplementary Data 11). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.