Interrogating individual genes constituting the TP53 TF regulon revealed the greatest increases in ALS iPSMNs in TNFRSF10B, SESN1, RRM2B, CDKN1A, ZMAT3 and MDM2. These integrated analysis results can be easily explored in the interactive web application at https://oliverziff.shinyapps.io/als_genome_instability/. The gene discussed is TF; the disease is amyotrophic lateral sclerosis.