We found a similar pattern in post-mortem samples, with non-TDP-43 ALS showing smaller less-significant increases in p53 signaling and TP53 TF activity (p53: NES + 3.6, p = 0.03; TP53: NES + 3.3, p = 0.01) as compared to TDP-43 ALS (p53: NES + 5.2, p < 0.001; TP53: NES + 2.0, p = 0.5; Supplementary Fig. 15c, d). Here, TP53 is linked to amyotrophic lateral sclerosis.