PROGENy revealed that the most substantial pathway activity increase in ALS iPSMNs was in p53 (NES + 13.0, p < 0.001), followed by Mitogen-Activated Protein Kinase (MAPK; NES + 5.6, p < 0.001), whilst the greatest decrease was observed in WNT (NES −2.5, p = 0.03; Fig. 2d). Here, WNK2 is linked to amyotrophic lateral sclerosis.