By examining splicing changes in neuronal nuclei depleted of TDP-4340, we found 12 overlapping differentially spliced genes (encompassing 17 splicing events) with ALS iPSMNs (including POLDIP3, PPP6R3, CAMK2B, CEP290; Supplementary Data 9)40. This evidence concerns the gene CEP290 and amyotrophic lateral sclerosis.