Regarding pyroptosis and necroptosis, Gsdmd–/– mice, Mlkl–/– mice as well as Gsdmd–/–Mlkl–/– mice cleared the infection with normal kinetics, showing that neither GSDMD-mediated pyroptosis nor MLKL-mediated necroptosis were essential for host defense against C. rodentium. The gene discussed is GSDMD; the disease is infection.