Indeed, C. rodentium infection of Casp8–/–Ripk3–/–Casp1–/– mice recapitulated the infection-induced lethality of Casp8–/–Ripk3–/–Casp1/11–/– mice, while both Casp8–/–Ripk3–/–Casp11–/– and Casp8–/–Ripk3–/–Gsdmd–/– mice survived the infection. The gene discussed is CASP8; the disease is infection.