Intriguingly, ablating Gsdmd on a Casp8–/–Ripk3–/– background did not reproduce the C. rodentium lethality phenotype as obtained after Casp1/11 deletion, as all Casp8–/–Ripk3–/–Gsdmd–/– mice survived the infection (Fig. 8A). This evidence concerns the gene RIPK3 and infection.