NOS3 and endothelial dysfunction: However, nitrates commonly have short-term efficacy, and the poor tolerance limits their further use.494 Some drugs, reported in animal models, such as statins and Ang II receptor blockers (ARBs) may activate eNOS or increase eNOS expression to improve endothelial dysfunction.495–497 In addition to these clinically used drugs, other antihypertensive drugs targeting NO-(NOsGC)-cGMP signaling pathway are still under exploration.