AGT and Hypertension: Activation of NLRP3 inflammasome (including NLRP3 sensory component, the adaptor protein ASC) is a powerful mediator of inflammatory response via the effector protein caspase-1, and plays a pivotal role in vascular diseases.330–332 Study showed that NLRP3 inflammasome activation contributed to VSMC phenotypic transformation and proliferation in hypertension.333 And CaSR (calcium-sensing receptor)-mediated activation of the NLRP3 inflammasome in VSMCs is an important regulator of aortic remodeling in SHRs induced by Ang II.334