It is noteworthy that, such anti-inflammatory effects may be unrelated to their BP-lowering effects and instead may be due to their ability to directly counteract the pro-inflammatory effects induced by Ang II.602 Statins may have anti-inflammatory effects and can lead to a small decrease in systolic BP in patients with hypercholesterolemea, by reducing pro-inflammatory cytokines levels.603 Some immunosuppressant drugs have potential as a treatment for hypertension, too. This evidence concerns the gene AGT and hypertensive disorder.