TFRC and neoplasm: Interestingly, in this study we found that overexpression of LncRIM slightly promoted M2 macrophage polarization, while knocking down both TFR1 and DMT1 significantly decreased the number of M2 macrophages and increased the number of M1 macrophages (Fig. S5m), providing evidence for a potential link to lncRNA-mediated iron metabolism of tumor cells and the macrophage polarization and functional abnormalities in the TME, but the underling mechanism is still unknown.