While cross-linking of CD16b only induces Ca2+ mobilization and degranulation, but not phagocytosis and cytolysis in neutrophils28,50, it will still be of interest in future studies to perform a systematic comparison on the abilities of CD3ζ- and CD16bγ-CARs in triggering and enhancing anti-tumor functions of neutrophils. This evidence concerns the gene FCGR3B and neoplasm.