Having found that Sftpc-hACE2-NF/F mice can support SARS-CoV-2 GFP/ΔN trVLP replication in lung tissues, we subsequently examined whether Sftpc-hACE2-NF/F mice develop interstitial pneumonia upon SARS-CoV-2 GFP/ΔN infection. This evidence concerns the gene SFTPC and infection.