Intriguingly, the deletion of the fellow autism candidate gene Nlgn3 also leads to a slight increase in network inhibition in the dentate gyrus (Muellerleile et al., 2022), which suggests that increased inhibition might underlie some of the behavioral symptoms observed in Nlgn3 and Nlgn4 KO mice and in individuals with autism-associated neuroligin mutations. This evidence concerns the gene NLGN3 and autism.