Interestingly, reports suggest that hyperactivation of Akt to pathological levels also causes vascular malformations and increased vascular permeability in several vascular beds, including the retinal vasculature [15], suggesting that a ‘fine-tuning’ of Akt activity is necessary for healthy vasculature and that either a significant reduction or hyperactivation will likely result in vascular malformations. Here, AKT1 is linked to vascular malformation.