Sex, age, BMI, current tobacco smoking and alcohol intake, family history of CKD (defined as any prevalent history of CKD among any first-degree relative), history of hypertension, evolution of diabetes mellitus, current diabetes mellitus treatment scheme (insulin, oral hypoglycemics, or both), microvascular complication of type 2 diabetes (retinopathy, diabetic foot, neuropathy, or stroke), fasting plasma glucose, HbA1c, serum creatinine (isotope dilution mass spectrometry), eGFR (Chronic Kidney Disease Epidemiology Collaboration equation), total cholesterol, triglyceride levels. The gene discussed is INS; the disease is Hypertension.