Considering that most of the identified sDEPs were specific to the intestine and lymphoid tissues and have a known role in the immune system, we correlated sDEPs (n = 276) with established markers of inflammation that relate to non-AIDS comorbidities (soluble CD163 [sCD163], sCD14, IL6, high-sensitivity C-reactive protein [hsCRP], and D-dimer) (32–34) and microbial translocation (IFABP) (24) measured in PLHIV in the discovery cohort. Here, IL6 is linked to AIDS.