Furthermore, 10 proteins that were downregulated include proteins that are highly expressed in the brain and associated with behavioral or psychiatric disorders (NPY, CNDP1, CBLN4, TNR), promote gut mucosal healing (CCN1), are related to inflammatory responses (CLEC4A, IL4R, TNFSF11), and are involved in bone resorption and remodeling (ITM2A, TNFSF11). This evidence concerns the gene ITM2A and psychiatric disorder.