PRDM16 and triple-A syndrome: Moreover, we analyzed the expression of Prdm16 in mouse VSMCs from 3 single-cell RNA-seq data sets (GSE152583, elastase-induced AAA, ref. 19; GSE164678, CaCl2-induced AAA, ref. 20; and PRJCA006049, angiotensin II–induced AAA, ref. 21), and the results showed significantly decreased expression of Prdm16 in VSMCs from AAA mice compared with control mice (Supplemental Figure 3).