Our colocalisation approach is generally more conservative and may fail to accurately determine the posterior probability for shared genetic signals in the presence of multiple independent associations in a given locus (Hukku et al., 2021), which may be a reasonable explanation for the lack of colocalisation observed at RTEL1 locus, and we stress that many of the variants that are COLOC negative are likely to be associated with lung cancer. The gene discussed is RTEL1; the disease is lung cancer.