Colocalisation analyses for the variants selected as the MR genetic instrument highlighted shared genetic signals between LTL and lung adenocarcinoma, including loci near genes related to telomere length maintenance (TERT, TERC, and OBFC1) and three genetic loci not previously linked to lung cancer susceptibility (POLI, PRPF6, and MPHOSPH6). The gene discussed is POLI; the disease is lung adenocarcinoma.