The finding of increased levels of plasma GFAP among individuals with and without dementia who had plasma P-tau181 or P-tau181/Aβ42 biomarker-positive status is consistent with previous studies.23,24,25 The GFAP intermediate filament-III protein is found in several cell types, including astrocytes in the central nervous system, and correlates with Aβ plaque density. Here, GFAP is linked to dementia.