CYP2C19 and epilepsy: However, several studies involving patients with epilepsy did not demonstrate any drug-drug interaction between CBD and clobazam, whereas exposure to N-desmethyl clobazam was enhanced by 2- to 3-fold, probably resulting from the inhibition of CYP2C19 by CBD, which leads to clobazam dose adjustments in the presence of CBD.78,81,82,87