Furthermore, ME2 silencing decreased glutamate utilization in AML cells, as evidenced by a higher glutamate level in ME2-silenced HL-60, THP-1, and MV4-11 AML cells than in the control group of AML cells (Fig. 1H), indicating a positive role of ME2 in glutamate utilization of AML cells. Here, ME2 is linked to acute myeloid leukemia.