ME2 and acute myeloid leukemia: The decreased OCR, including the mitochondrial proton leak and ATP produced by oxidative phosphorylation, as well as the decreased ATP, pyruvate, and NADH levels in ME2-silenced HL-60, THP-1, and MV4-11 AML cells (Fig. 1B and E, and 1 F, respectively), provided conclusive evidence that ME2 regulates energy metabolism through cellular respiration and oxidative phosphorylation.