ME2 and acute myeloid leukemia: The OCR was significantly decreased in ME2-silenced HL-60, THP-1, and MV4-11 AML cells (Figures S3A, 1I, and 1J, respectively), as evidenced by the basal (Figures S3B, S3C, and S3D, respectively) and maximal respiration (Figures S3E, S3F, and S3G, respectively), as well as the spare respiration capacity (Figures S3H, 1 K, and 1 L, respectively), the mitochondrial proton leak (Figures S3I, 1 M, and 1 N, respectively), and the amount of ATP generated by mitochondrial electron transport (Figures S3J, 1O, and 1P, respectively).