To further evaluate the role of ME2 in vivo development of leukemia, ME2-silenced THP-1 and MV4-11 AML cells as well as control cells were implanted into mice with advanced severe immunodeficiency (ASID); the percentage of CD33 + and CD45 + cells in the peripheral blood (PB) and bone marrow (BM) compartments were used to assess the burden of AML (Fig. 3A). This evidence concerns the gene PTPRC and acute myeloid leukemia.