IFNA1 and cancer: In a recent article published in Cancer Cell, Ma et al. [1] identified a novel cancer-associated fibroblast (CAF) subtype termed interferon-regulated CAF (irCAF) in bladder cancer (BC), which was specifically induced by the type I interferon (IFN) within the tumor microenvironment (TME) and closely associated with unfavorable prognosis and low therapy response in patients.