SSP is a metabolic vulnerability in EGFR‐mutated cancer.[8] PHGDH is the first rate‐limiting enzyme of the SSP and plays an important role in tumor resistance to serine starvation,[9] reactive oxygen species (ROS) imbalance,[10] sorafenib resistance,[11] and brain metastasis.[12] However, whether and how Phgdh regulates the progression of liver cancer is elusive. The gene discussed is PHGDH; the disease is neoplasm.