Our previous study showed that UGDH localizes to the nucleus and binds HuR, eliminating UDP‐glucose‐mediated inhibition of HuR.[40] Recently, a report demonstrated PHGDH enters the nucleus in pancreatic cancer under nutrient stress and exhibits an alternative activity.[41] Thus, our study first uncovered a non‐metabolic role of nuclear PHGDH. Here, PHGDH is linked to pancreatic neoplasm.