S100a8 and S100a9 play pro‐tumorigenic roles in carcinogen‐induced HCC.[21] The expression changes in Phgdh, Psat1, S100a8, S100a9, and a few members of the cytochrome C family were validated by quantitative real‐time PCR (qRT‐PCR) (Figure 1E). The gene discussed is S100A8; the disease is hepatocellular carcinoma.