To examine whether and how the oncogenic role of cMyc in the progression of liver cancer is regulated by PHGDH, we analyzed the RNA profiles of PLC/PRF/5 cells expressing WT or dACT PHGDH and GO enrichment analyses showed that the NOD‐like receptor‐related pathway ranked first among the differentially expressed genes (Figure 5A). This evidence concerns the gene MYC and liver cancer.