For example, melanoma cells express several chemokines, including CXCL1/2/3, IL8, and CCL2/5, which have been implicated in tumor growth and progression.[19] Herein, liver cancer cells expressed and secreted CXCL1/2, IL8, IL1B, and CCL5, most of which match the chemokines expressed by melanoma cells. This evidence concerns the gene IL1B and liver cancer.