CXCL1 and neoplasm: In addition to hepatocytes, there are non‐parenchymal cells in liver tissue, especially macrophages and neutrophils, which form an immune network to mediate immune cell infiltration in the tumor stroma and play a vital role in driving tumor progression.[16, 17] CXCL1 and IL8, secreted by macrophages, monocytes, or other cells, direct neutrophil recruitment to the liver and promotes liver cancer progression.[28, 29, 30, 31, 32] Compared to control liver cancer cells, antibody‐neutralized or genetically modified PHGDH‐dACT cells exhibited reduced neutrophil recruitment (Figure 6C).