To examine whether and how the oncogenic role of cMyc in the progression of liver cancer is regulated by PHGDH, we analyzed the RNA profiles of PLC/PRF/5 cells expressing WT or dACT PHGDH and GO enrichment analyses showed that the NOD‐like receptor‐related pathway ranked first among the differentially expressed genes (Figure 5A). The gene discussed is HSPG2; the disease is liver cancer.