Most studies confirm a link between elevated Lp(a) and increased incidence of aortic valve disease.21,50 There are also data supporting a dose-dependent effect.14,27,30,31,47,48 Genetic factors may contribute to this relationship, with the LPA SNPs rs10455872 (allele G) and rs3798220 (allele C) displaying the most prominent effects. The gene discussed is LPA; the disease is aortic valve disorder.