• Lp(a) higher in CAVD group [12 (4–48) vs. 8 (4–24) mg/dL; P < 0.001].• For every 10 mg/dL-increase in Lp(a) aOR: 1.10 (95% CI: 1.06–1.13) for CAVD.• OxPL-apoB and OxPL-apo(a) correlated with Lp(a) and associated with CAVD. The gene discussed is LPA; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.