The insertion of a Tyk‐binding motif copied from a IFNAR1 fragment into the 4‐1BB ICD is considered to extend the persistence and cytotoxic function of T cells.[33, 34] The incorporation of an additional ITAM copied from a DAP‐12 fragment into the C‐terminal residues of the CD3ξ ICD aims to enhance cytotoxic function with low cytokine production.[35] The secretable bivalent PD‐L1 Nb‐BiTE moiety with two different PD‐L1‐targeted Nb clones and a CD3ɛ Nb is designed to maximize the binding affinity to PD‐L1 and engage PD‐L1‐expressing tumor cells with CD3+ T cells. Here, CD274 is linked to neoplasm.