In order to show how the expression level of main apoptotic factors, such as BCL2 and BAX, can influence the occurrence of resistance, and whether their influence is independent from the impact of multi drug resistance (ABCB1) gene expression level, in this study we investigated the expression pattern of these genes, and examined the possibility of their mutual influence on the prognosis in AML-NK patients. This evidence concerns the gene BCL2 and acute myeloid leukemia.