As the overexpression of pro-survival BCL-2 proteins is not only a hallmark of cancer progression but also critical for tumor cells to sustain a high proliferative rate and survive genomic instability, apoptosis modulation has been proposed as a therapeutic approach to selectively target cancer cells for elimination (Hanahan and Weinberg, 2011; Delbridge et al., 2016). Here, BCL2 is linked to cancer.