SYP and type 1 diabetes mellitus: Alternatively, previous studies (Duarte et al., 2009; Gardoni et al., 2002; Luca et al., 1999), except for one (Hou et al., 2012), measured SYP and GluN2B protein levels specifically in the membrane or PSD fraction; thus, the localization, but not total expression, of SYP may change in the hippocampus of T1D mice.