Previous work involving the knockout of Homer1 and GluN1 has elucidated their roles in learning and psychiatric disorders (McHugh et al., 2007; Nakazawa et al., 2002; Szumlinski et al., 2005), leading us to speculate that their downregulation may contribute to T1D‐related disturbances in synaptic plasticity and memory. This evidence concerns the gene GRIN1 and type 1 diabetes mellitus.