In the study conducted by Huang et al38 in 2015, on the expression and diagnostic value of HE4 in pancreatic adenocarcinoma, they presented data showing increased HE4 mRNA and protein expression in pancreatic adenocarcinoma tissues and high HE4 serum levels in patients with pancreatic adenocarcinomas. This evidence concerns the gene WFDC2 and pancreatic adenocarcinoma.