A crossover trial involving 12 T2DM patients with obesity with different interventions including ARNIs alone or ARNIs plus DPP4 inhibitors showed that ARNIs increase postprandial blood glucose by 57% with increasing levels of glucagon, C‐peptide, and GLP‐1 without effect on GIP and insulin levels.15 Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.