CCL3 and Heat Stroke: In primary cultured astrocytes, scRNA-seq and qPCR showed upregulation of C6, CCL3, and CCR1 after heat stress but downregulation in heat stroke rats (Niu et al., 2017), while the transcriptional levels of CCL3 and CCR1 were downregulated in heat stroke rats (Audet et al., 2016).