TRAF2, a key protein for transmitting apoptotic signals from the endoplasmic reticulum to the cytoplasm, can effectively inhibit the apoptotic process mediated by death receptors, and accordingly, the activated intracellular IRE1 protein can integrate with the downstream target protein TRAF2 to form a complex that inhibits apoptosis of tumor cells. Here, TRAF2 is linked to neoplasm.