Antigen presentation is a critical stage in eliciting anti-tumor responses by ICT (51), which is not restricted to tumor peptides presented via MHC molecules to T cells, but includes antigen presentation via MHC-associated molecules, such as β2M and CD1d, which presents non-peptide (glycolipid) antigens, such as α-galactosylceramide (αGalCer), to antitumor NKT cells (52, 53). Here, B2M is linked to neoplasm.