B2M and neoplasm: Taking into consideration recent findings on the epigenetic impact on β2M and associated faults in MHC-dependent peptide presentation leading to ICT resistance, we sought to investigate whether β2M deficiencies could also indicate deficiencies in other MHC family molecules, such as CD1d, and consequently, pointing a potential deficiency in the presentation of tumor glycoproteins and glycolipids as a contributing factor to ICT resistance.