HLA-C and cancer: The top GO terms in the CC module were endocytic vesicle membrane, endocytic vesicle, and cytosolic small ribosomal subunit, and regarding MF, Tex-related hub genes were mainly enriched in MHC protein complex binding (Figure 3A). KEGG enrichment analysis containing T cell receptor signaling pathway, virus infection, and PD-L1 expression and PD-1 checkpoint pathway in cancer (Figure 3B).