PRF1 and neoplasm: Genes associated with increased cytotoxicity (GZMB, GAMH, PRF1- (22)), IFN-γ production (ANXA1- (23)), cellular adhesion and migration (ITGB1- (24), ITGB2, CCL5- (25)) and anti-tumor activity (HLA-DPA1, NKG7- (26)) were enriched, while genes encoding proteins that suppress immune function and differentiation (MALAT1- (27), TXNIP - (28), FOXP1- (29)) were downregulated.