IGFBP7 and acute kidney injury: Novel biomarkers like tissue inhibitor of metalloproteinases-2 (TIMP-2), neutrophil gelatinase-associated lipocalin (NGAL), and insulin-like growth factor binding protein-7 (IGFBP-7) have been evaluated to forecast the prognosis of S-AKI; however, their sensitivity has not been verified in large multicenter studies (12).