Interestingly, published scRNA-sequencing datasets generated from severe COVID-19 patients demonstrate increased transcript reads of IL-1β and TNF-α from bronchoalveolar lavage fluid (BALF) macrophages (38), supporting their hypothesis that proinflammatory reprogramming of lung macrophages and/or precursor monocytes may drive prolonged and exacerbated PASC symptomology. The gene discussed is TNF; the disease is long COVID-19.