NLRP3 and neoplasm: Interestingly, here we also found that macrophage-depletion of NLRP3 significantly reduced cytotoxic T cells in the EMC tumor, likely due to the altered interaction between TAMs and lymphocytes (29), which is consistent with a previous study that demonstrated a role of macrophagic NLRP3 signaling in regulation of T-cell differentiation and a phenotypic shift between tumor-suppressing type 1 T helper cells and tumor-promoting type 2 T helper cells (30).