CD38 and hepatocellular carcinoma: The expressions of CD38 and HLADR on CD8+ T cells in peripheral blood of HBV-HCC patients were significantly higher than those of healthy volunteers (p <0.0001), and the expressions of CD38 and HLADR on CD8+ T cells in peripheral blood of HBV-LC patients were significantly higher than those of healthy volunteers (p <0.0001), but there was no statistical difference between HBV-HCC and HBV-LC patients (Figure 2B).