BIRC5 and alcohol dependence: As shown in Figure 8A, the main pathways correlated with high expression of BIRC5 were focal adhesion, human papillomavirus infection, protein processing in endoplasmic reticulum, pathways in cancer, and MAPK signaling pathway and the main pathways related to low expression of BIRC5 were alcoholism, neutrophil extracellular trap formation, olfactory transduction, systemic lupus erythematosus (Figure 8B).