Our previous study has revealed that the combination of geniposide and chlorogenic acid (GC) improves and reduces high-fat diet (HFD)-induced NASH, improves intestinal barrier function (Peng et al., 2018), and downregulates the expression of stearoyl-CoA desaturase (Δ-9-desaturase) (SCD1) in NAFLD mice (Chen et al., 2021). The gene discussed is SCD; the disease is metabolic dysfunction-associated steatohepatitis.