ADH1C and colorectal carcinoma: Bongaerts et al. (2011) considered that the ADH1C genotype and excessive alcohol intake were associated with an increased risk of CRC, while some researchers have suggested that ADH1C expression is reduced during the progression of CRC from early to advanced stages. ADH1C allele mutations were related to an increased breast cancer risk due to alcohol consumption by comparing postmenopausal breast cancer samples with controls (Benzon Larsen et al., 2010). However, one study suggests that ADH1C polymorphisms may not be connected with breast cancer in Caucasians (Wang et al., 2012).