Chicoric acid can inhibit the levels of NF-κB, NLRP3, caspase-1, and IL-1β in the kidney tissue of rats with MTX-AKI while reversing Bcl-2 and the expression of Bax and caspase-3, thus, exerting anti-inflammatory effects and inhibiting apoptosis (Abd El-Twab et al., 2019). This evidence concerns the gene CASP3 and acute kidney injury.