The phosphatidylinositol3-kinase (PI3K)/protein kinase B (Akt) pathway mitigates apoptosis, and PI3K knockout leads to excessive apoptosis in renal tubular epithelial cells, indicating its presence in CP-AKI, supporting the key role of kidney function (Kuwana et al., 2008). The gene discussed is AKT1; the disease is acute kidney injury.