Ginsenoside Rg3 improves kidney damage in HK-2 cells and mice by upregulating LC3II/I and Beclin-1 while inhibiting p62, NLRP3, caspase-1, and IL-1β, suggesting that activating the autophagy-mediated inhibition of NLRP3 may be a novel way to prevent CP-AKI (Zhai et al., 2021). Here, NLRP3 is linked to acute kidney injury.