FASN and melanoma: In human melanoma cells, inducible HSF1 knockdown results in increased sterol regulatory element-binding protein 1c (SREBP1c) Ser372 phosphorylation, decreased levels of acetyl-CoA carboxylase (ACC1), fatty acid synthase (FASN), LDLR, and 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) mRNAs, and reduced SREBP1's nuclear translocation and binding to genomic DNA (8).