GCLC and cancer: Nrf2 induced the expression of many detoxification phase II enzyme genes such as glutamate cysteine ligase catalytic subunit (GCLC), catalase (CAT), and glutathione peroxidase-1 (GPX1), which are reported in this study, and the function of these phase II enzymes is mainly to metabolize harmful carcinogens to inert metabolites, which could prevent the formation of cancer.