Nrf2 induced the expression of many detoxification phase II enzyme genes such as glutamate cysteine ligase catalytic subunit (GCLC), catalase (CAT), and glutathione peroxidase-1 (GPX1), which are reported in this study, and the function of these phase II enzymes is mainly to metabolize harmful carcinogens to inert metabolites, which could prevent the formation of cancer. This evidence concerns the gene GPX1 and cancer.