CTCF and central nervous system cancer: For example, deletion of CTCF in the domain may result in an interaction between the enhancer and a glioma oncogene (Katainen et al., 2015); the binding site of CTCF is the main mutation hot spot of the non-coding cancer genome (Ohlsson et al., 2001); zinc finger mutation or abnormal target selective methylation destroy the spectrum of target specificity and is related to cancer (Phillips and Corces, 2009).