Hypohidrotic ectodermal dysplasia (HED) is the most highly represented ED and is proven to be affected by mutations in EDA, EDAR, and EDARADD in most cases (Cluzeau et al., 2011; Martínez-Romero et al., 2019; Ahmed et al., 2021). The gene discussed is EDAR; the disease is hypohidrotic ectodermal dysplasia.