STING1 and COVID-19: This suggests that, during Sars-CoV-2 infection, STING may have a bivalent function: on one hand, it could lead to the worsening of COVID-19 condition in the case of its prolonged over-activation and subsequent excessive cytokines expression; on the other hand, it contributes to block viral replication and spreading through the induction of a robust IFN response.