Thanks to its ability to sense both non-self and endogenous cytosolic and/or nuclear dsDNA, STING pathway plays a central role not only in immune response against microbial infections, but also in autoimmunity, inflammation, senescence and cancer, acting as a regulator of IFN-I and NF-κB expression (Motwani et al., 2019). The gene discussed is STING1; the disease is cancer.