Recent work has highlighted the importance of brain insulin sensitivity in AD (de La Monte, 2012; Kerr and Booth, 2022); insulin signaling in the brain has been demonstrated to inhibit neuronal apoptosis as well as regulate tau phosphorylation and amyloid beta clearance (Neumann et al., 2008; Kellar and Craft, 2020). This evidence concerns the gene INS and Alzheimer disease.