VSIR and central nervous system cancer: V-domain immunoglobulin suppressor of T cell activation (VISTA) complexly and reciprocally perform as ligand and receptor in the positive and negative control of cancer immunity.81, 82, 83IgSF11 (immunoglobulin superfamily 11 gene), a VISTA ligand, demonstrates raised expression notably in high-grade glioma and corresponds with poor prognosis, implying the promising prognostic significance of IgSF11 and VISTA.84