Moreover, it is known that for a solid tumor to migrate, it must first invade the ECM, and therefore, its enzymes are a major factor that can influence the metastatic progression of carcinomas.14More specifically, several studies have validated that the expression of MMP-9 is associated with a higher risk of metastasis and a lower survival expectancy in different types of cancer.15, 16, 17. Here, MMP9 is linked to cancer.