NFE2L2 and idiopathic pulmonary fibrosis: An imbalance between the levels of NOX4 and nuclear factor-erythroid 2-related factor 2 (NRF2) promotes the pathogenesis of lung fibrosis by enhancing cellular senescence in myofibroblasts, resulting in resistance to apoptosis and persistent fibrosis during IPF pathogenesis (80, 81).