Activated AKT inhibits the inflammatory reaction in mice and rabbits with LPS-induced sepsis, and the possible mechanisms may be attributed to increased IL-12, TNF-α, and IL-6 (proinflammatory cytokines) levels and decreased IL-10 (an anti-inflammatory cytokine) levels after PI3K or AKT is inhibited [19,20]. This evidence concerns the gene AKT1 and Sepsis.