However, our study showed that the leukocyte count was significantly increased in rats after LPS-induced pulmonary infection, but AKT2 inhibition did not result in leukocytopenia, which suggested that AKT2 and its downstream cytokines were not the key genes that led to leukocytopenia after infection and that postinfection leukocytopenia might be the consequence of decreased AKT2 activity due to immunosuppression. This evidence concerns the gene AKT2 and infection.