We found that compared with the control group, the infection model group, which was induced by LPS, showed significantly increased p-mTOR levels in macrophages, as well as increased levels of LC3B II and Beclin1 (mitochondrial autophagy markers in macrophages); after AKT2 inhibition, LC3B II and Beclin1 levels were further increased, although the pathological changes were not noticeable, compared with those in the infection model group, suggesting that AKT2 inhibition might further exacerbate postinfection mitochondrial autophagy. The gene discussed is AKT2; the disease is infection.