In addition, the IL-10 rs1800896 gene polymorphism increased the risk of laryngeal SCC (AG/AA: OR = 1.41, 95% CI: 1.04–1.93, p = 0.030), esophageal SCC (AG + GG/AA: OR = 0.48, 95% CI: 0.32–0.72, p = 0.000). This evidence concerns the gene IL10 and esophageal squamous cell carcinoma.