In a linear regression analysis including age, sex, presence of ICH, hypertension, hyperlipidemia, pWMH, and CTh as independent variables and PSMD as the dependent variable, only higher pWMH (ß = 1.40, 95% CI 1.05–1.75, p < 0.001) was independently associated with increased PSMD. Here, CTH is linked to hyperlipidemia.