Xu et al. (2020) identified that plasma lncRNA SNHG1 could be a CRC marker for diagnosis. We noticed that some lncRNAs, such as CCAT1, PVT-1, MEG3, and H19 that proved to be significantly upregulated in CRC tissues compared with the normal tissues, were found to be promising plasma diagnostic biomarkers, especially for distinguishing early-stage CRC (Liu et al., 2019). Here, MEG3 is linked to colorectal carcinoma.